The X-Men don't exist in Marvel's Wolverine, and while Spider-Man does, he'll only appear fleetingly in an "Easter-eggy" kind of way

Insomniac confirmed the X-Men don't exist in Marvel's Wolverine; instead Logan teams with "Team X" including Sabretooth and Jean Grey, who assists in combat. Spider-Man exists in the same universe but appears only as an "Easter-eggy" reference with no crossover.

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